BTP - Faculty Trainers

Name/Department Name	Research Interest (from our files)	Phone Number/Email
Nicholas L. Abbott Chemical and Biological Engineering	Exploiting the liquid crystalline state of matter to amplify and transduce recognition events between biological molecules. Designing interfaces that present a range of recognition moieties such that specific binding of biological molecules to these moieties can trigger a change in the orientation of supported liquid crystalline phase	265-5278/262-5434 abbott@engr.wisc.edu
Paul Ahlquist Molecular Virology (Plant Pathology)	Molecular mechanisms of virus replication, gene expression, evolution and virus-host interactions for several important classes of RNA viruses and tumor viruses.	263-5916/262-4540 ahlquist@facstaff.wisc.edu
Elaine Alarid Physiology	Molecular mechanisms of Steroid Hormone Action	265-9319 alarid@physiology.wisc.edu
Richard Amasino Biochemistry	The mechanisms that control flowering and the transition of meristems from vegetative to reproductive development. Particularly, the mechanisms that plants have evolved to regulate flowering in response to environmental cues such as changes in day length or temperature.	262-4704/262-4640 amasino@biochem.wisc.edu
Richard A. Anderson Pharmacology	Understand how signaling pathway regulate cellular processes. Focused on signals that regulate the epithelial to mesenchymal transition, a key component in the metastasis of cancers and defining how phosphoinositide signals regulate events within the nucleus.	262-3753/262-1733 raanders@wisc.edu
Jean-Michel Ane Agronomy	Understanding how symbiotic associations between plants and microbes develop is an important biological question that is particularly relevant in modern agriculture.	262-6457 jane@wisc.edu
Aseem Zoe Ansari Biochemistry	Understand the mechanistic events that culminate in the expression of specific genes, and to develop artificial transcription factors capable of regulating the expression of targeted genes.	265-4690 ansari@biochem.wisc.edu
Alan D. Attie Biochemistry (Comparative Biosciences)	Identification of gene conferring susceptibility of diabetes, biochemistry of nutrient sensing and insulin secretion by pancreatic beta cells. Molecular and cell biology of lipoprotein assembly and secretion	262-1372 attie@biochem.wisc.edu
Craig Atwood Medicine Cell & Molec. Biology	Proposed a novel theory of aging based on the modulation of cell cycle signaling by reproductive hormones.	256-1901 csa@medicine.wisc.edu
James D. Bangs Medical Microbiology	Basic cellular and biochemical aspects of the pathogenic protozoa of the genus Trypanosoma. Primarly, the nature intracellular protein trafficking and secretion using T. brucei.	262-3110/Fax 262-8418 jdbangs@wisc.edu
David Baum Botany	Analyses DNA sequences data to address problems in evolutionary biology (phylogeny, molecular evolution, speciation, reticulate evolution, etc.). A second major focus is on evolutionary developmental genetics, in particular, we conduct interspecies transformation experiments to evaluate the role that particular genes and regulatory regions have played in the morphological divergence among plant species.	265-5385 dbaum@facstaff.wisc.edu
Sebastian Bednarek Biochemistry	To characterize the transport of proteins, cell wall precursors and membrane components of the machinery involved in the establishment of the division plane and in the process of cell-plate assembly.	(608)263-0309 bednarek@biochem.wisc.edu
David J. Beebe Biomedical Engineering	Aimed at the intelligent development and use of micro (cellular) scale technologies and phenomena to solve problems in medicine and biology. Current areas of focus include the effect of microenvironment on living systems and the use of responsive materials to create autonomous systems.	262-2260 djbeebe@wisc.edu
Paul J. Bertics Biomolecular Chemistry	Characterizing the regulation of cell proliferation and function by growth factors, cytokines and bacterial toxins (i.e., endotoxin). Currently, assessing the mechanisms by which purinergic receptors and cytokine receptor signaling cooperate to regulate leukocyte activation and immune responses	262-8667/262-6206 pbertics@wisc.edu
Helen Blackwell Chemistry	Developing an integrated chemical biology research program that uses complex molecules derived from organic synthesis to probe important problems in biology, particularly in the areas of cancer and photobiology.	(608) 262-1503 blackwell@chem.wisc.edu
Robert Blank Endocrinology Cell & Molec. Biology	Practices general endocrinology with a special emphasis on disorders of bone and mineral metabolism, hereditary endocrine disorders, and endocrine issues in cancer. He is a member of the Osteoporosis Clinical Center and Research Program. Particular interests include bone dysplasias and the multiple endocrine neoplasia syndromes.	263-5010 rdb@medicine.wisc.edu
Frederick Blattner Genetics	Targeted genetic alteration of mammals (mouse); DNA sequencing methodologies; total sequencing of E coli genome; global regulation of expression of genes in bacteria; mechanisms of expression of immunoglobulins; DNA cloning methodologies and cloning vectors; mechanism of replication in bacteriophage lambda.	890-0191/262-1973 fred@genome.wisc.edu
Wally Block Biomedical Engineering	Magnetic resonance (MR) interventional procedures.MR angiography and cardiac imaging - specifically designing real-time magnetic resonance acquisition and processing algorithms and systems for these procedures	265-9686 wfblock@wisc.edu
Curtis R. Brandt Medical Microbiology & Immunology (Molecular Virology)	Virology - Pathogenesis of herpes simplex virus; virulence genes in herpetic eye disease and herpes encephalitis; antiviral; interactions between cytokines and herpes viruses, and gene delivery, gene therapy.	262-8054/262-8055 crbrandt@wisc.edu
Emery Bresnick Pharmacology	Transcriptional Control Mechanisms; Stem Cell Biology; Hematopoiesis and Vasculogenesis	265-6446/262-1733 ehbresni@facstaff.wisc.edu
David A. Brow Biomolecular Chemistry	Mechanisms of eukaryotic gene expression, especially DNA transcription and RNA processing, studied in yeast. Our focus is on small nuclear RNA synthesis and function, and nucleic acid-protein interactions.	262-1475/265-5704 dabrow@wisc.edu
Richard R. Burgess Oncology	Transcription profiling and DNA microarray design and use and involvement with high-throughput screening and drug discovery, and in carrying out physical chemical studies of protein-protein binding.	263-2635 rburgess@wisc.edu
Samuel Butcher Biochemistry	Structure, function and dynamics of RNA. RNA plays a central role in many biologically important processes, including peptide bond formation, pre-messenger RNA splicing, viral processing and maturation, and chromosome maintenance. RNA performs the actual chemical or catalytic steps of the reactions. Uses both biophysical and biochemical techniques, with a strong emphasis in NMR spectroscopy. NMR is ideally suited for both atomic resolution structure determination and the study of dynamic processes in solution. Current focus is aimed at revealing the U2 and U6 RNA structures involved in catalyzing pre-mRNA splicing.	262-3040 butcher@nmrfam.wisc.edu
Edwin Chapman Physiology (Neuroscience)	Goal is to elucidate the molecular mechanism that mediates the release of neurotransmitters from neurons. The studies are focused on the Ca²⁺-triggered fusion of synaptic resides with the pre-synaptic plasma membrane.	263-1762 chapman@physiology.wisc.edu
Naomi Chesler Biomedical Engineering	Vascular remodeling in systemic and pulmonary hypertension; Pulmonary vascular resistance and impedance; Ventricular-vascular coupling; Cardiovascular tissue engineering; Vascular gene therapy	265-8920 chesler@engr.wisc.edu
Joshua Coon Chemistry	Bioanalytical Chemistry – Mass Spectrometry	263-1718 jcoon@chem.wisc.edu
Michael Cox Biochemistry	The primary goal of our research is to understand recombinational DNA repair of double strand breaks, and its role in the repair of stalled replication forks. Another goal is to utilize the enzymes we study in the development of new methods in biotechnology.	262-1181/262-7982 cox@biochem.wisc.edu
Gheorghe Craciun Mathematics (Biomolecular Chemistry)	Mathematical and Computational Methods in Biology and Medicine	(608) 265-3391 craciun@math.wisc.edu
Elizabeth Craig Biomolecular Chemistry	Regulation and function of heat shock (stress) response. Studying response in yeast Saccharomyces cerevisiae, particularly the regulation of transcription of heat shock genes and proteins involved in regulation.	263-7105/262-1358 ecraig@wisc.edu
Mark W. Craven Biostatistics & Medical Informatics	Developing new computational methods for gaining scientific understanding from rich, biomedical data sources. In particular, machine learning, bioinformatics, and information extraction from text.	265-6181/263-0415 craven@biostat.wisc.edu
Cameron Currie Bacteriology	My research focuses on the ecology and evolution of symbiotic associations between animals and microbes.	265-8034/ 231-5845 currie@bact.wisc.edu
Juan DePablo Chemical and Biological Engineering	Thermodynamics, phase equilibria, statistical mechanics, polymer physics, molecular modeling and simulation, Molecular Thermodynamics/Statistical Mechanics Research Group; Rheology Research Center	262-7727 depablo@engr.wisc.edu
John Denu Biomolecular Chemistry	Mechanics and biological function of reversible protein modifications involved in modulating signal transduction, chromatin dynamics and gene activation.	265-1859 jmdenu@wisc.edu
Timothy Donohue Bacteriology	Cytochrome biosynthesis and its regulation; genetic analysis of bacterial photosynthesis.	262-4663 tdonohue@bact.wisc.edu
Diana M. Downs Bacteriology	Regulatory mechanisms that cells use to maintain an efficient metabolic balance under various growth conditions.	265-4630/263-3875 downs@bact.wisc.edu
Richard S. Eisenstein Nutritional Sciences	Regulation of iron homeostasis in eucaryotes through post-transcriptional modulation of the synthesis of proteins involved in iron storage and iron uptake. Regulation of protein synthesis in eucaryotes.	262-5830 eisenste@nutrisci.wisc.edu
Adnan Elfarra Comparative Biosciences (Environmental Toxicology)	Metabolism of toxicants and carcinogens, metabolite isolation and characterization of toxicants and target organ selectivity.	262-6518/262-3653 elfarraa@svm.vetmed.wisc.edu
Jorge Escalante-Semerena Bacteriology	Anaerobic bacterial metabolism.	262-7379/265-5314 escalante@bact.wisc.edu
Sean Fain Medical Physics	Application of MRI and PET to functional imaging of lung and kidney diseases. Perfusion MRI of cancer and computer aided diagnosis of breast cancer using compartmental modeling.	263-0090 fains@mr.radiology.wisc.edu
Donna Fernandez Botany	Molecular and cellular aspects of plant development. The regulation of plant embryo and seed development and control of maturation and abscission process in flowers	262-9033/262-7509 dfernand@facstaff.wisc.edu
Katrina Forest Bacteriology	Molecular structure and function of proteins which enable some bacteria to be pathogens, in particular, using x-ray crystallography to study the Type IV pilins.	265-3566/Fax 262-9865 forest@bact.wisc.edu
Brian G. Fox Biochemistry (Enzyme Institute)	Enzymatic mechanisms of production of unsaturated fatty acids and the degradation of xenobiotic compounds.	262-9708 bgfox@biochem.wisc.edu
Catherine Fox Biomolecular Chemistry	Mechanistic description of the assembly and structure of a heterochromatic domain. Regulation and function of two highly related members of the forkhead family of transcription factors that function in the cell cycle and the differentiation in budding yeast. Long term goal is to provide fundamental insights into how human cells use multiple related transcription factors, including members of the forkhead family, to control growth, differentiation and proliferation.	262-9370 cfox@wisc.edu
Darin Furgeson Pharmaceutical Sciences (Biomedical Engineering)	Thermosensitive elastin biopolymers for multimodal targeted cancer gene therapy. Thermo-targeted biomacromolecular drug delivery for abrogation of heat shock protein 90 (HSP90).	890-0699 dfurgeson@pharmacy.wisc.edu
Samuel Gellman Chemistry	Organic and biological chemistry, including; the design of new oligomers with well-defined folding properties ("foldamers"), and their use in antimicrobial therapy and other biomedical applications; protein origins of stability and specificity in inter- and intramolecular noncovalent interactions; new polymerization methods, including template-directed polymerization	262-3303 gellman@chem.wisc.edu
Heidi Goodrich-Blair Bacteriology	Molecular basis of bacterium-nematode-insect interactions	265-4537/262-9865 hgblair@bact.wisc.edu
Richard Gourse Bacteriology	The control of gene expression, primarily the mechanism of transcription initiation. Focusing on the architecture of transcription complexes the relationship between structure and function in subunits of RNA polymerase, and the mechanisms by which the transcription apparatus responds to signals from inside and outside of the cell.	262-9813/262-2419 rgourse@bact.wisc.edu
Daniel Greenspan Pathology	Extracellular regulatory molecules that play key roles in vertebrate development and homeostasis.	262-4676 dsgreens@wisc.edu
Anne Griep Anatomy	Using the embryonic eye to understand the biological activities of growth factors, cellular proto-oncogenes and tumor suppressor genes in development.	(608) 262-8988 aegriep@facstaff.wisc.edu
Jo Handelsman Plant Pathology (Bacteriology)	Molecular bases of interactions between plants and beneficial bacteria; biochemistry and genetic regulation of antibiotic production; microbial diversity.	263-8783/262-1410 joh@plantpath.wisc.edu
Jeff Hardin Zoology	Using the nematode, C. elegans, as our primary model system to understand the cellular and molecular basis of morphogenesis, i.e., how embryos change their shape during early development.	262-9634/265-2520 jdhardin@wisc.edu
Mike Havey Horticulture (Plant Breeding & Plant Genetics)	Genetics, genomics, and breeding for production, flavor, and health-enhancing attributes of major vegetable crops. Identification of molecular markers as indirect selection tools near major loci of economic importance. Development of genomic and bioinformatic resources for onion and other major plants in the monocot order Asparagales.	262-1830 mjhavey@wisc.edu
Colleen E. Hayes Biochemistry	Investigating the molecular basis for two diseases of the immune system, autoimmunity and immunodeficiency. Researching how the vitamin D endocrine system regulates the autoimmune disease multiple sclerosis. Study how the lymphocyte homeostasis underlies systematic lupus erythematosis, B cell immunodeficiency diseases, and follicular lymphoma.	263-6387/263-5376 hayes@biochem.wisc.edu
William J. Hickey Soil Science (Environmental Toxicology)	Biodegradation and bioremediation of pollutants, molecular tracking of microbes in the environment, molecular markers of stress and toxicant exposure	262-9018/262-2633 wjhickey@facstaff.wisc.edu
Christina Hull Biomolecular Chemistry	Understanding the regulatory mechanisms of sexual development in human fungal pathogens. The incidence of infection caused by fungi has risen sharply, and severe fungal infections are often life threatening and difficult to treat. As a group, the human pathogenic fungi have been difficult to study, but the fungus Cryptococcus neoformans has been useful in both molecular and genetic analyses, making it an excellent system for studying human fungal pathogens.	265-5441 cmhull@wisc.edu
Anna Huttenlocher Pediatrics (Pharmacology)	Aims to define the cellular and molecular mechanisms that regulate cell migration, and to link these molecular findings to human disease.	265-4642/265-4669 huttenlocher@wisc.edu
Thomas Jeffries Forest Products (USDA Lab) (Bacteriology)	Understand how to optimize the expression of multiple genes in a biochemical pathway so as to maximize the flow of metabolites into desired products. This is being applied in yeast systems using genes for various elements of pentose phosphate, glycolytic and respiration pathways.	231-9453/231-9262 twjerrfi@facstaff.wisc.edu
Robert Jeraj Medical Physics	The main focus is image-guided therapy, which uses medical imaging for improving accuracy of cancer treatment. Various imaging modalities, ranging from positron emission tomography (PET), magnetic resonance imaging (MRI) and computed tomography (CT) are used to assess early treatment response, which can lead to treatment modification with the goal of achieving better overall tumor control.	(608) 263-8619 rjeraj@wisc.edu
Jeffrey Johnson Pharmaceutical Sciences	Molecular Neuropharmacology/Neurotoxicology.	(608) 262-2893 jajohnson@pharmacy.wisc.edu
Weiyuan John Kao (1) Pharmacy (Biomedical Engineering)	Focuses on the role of biomaterial in the management of various pathological conditions. Overall, we (1) elucidate mechanisms involved in cell adhesion and activation on biomaterials, (2) delineate critical factors in material biocompatibility and biodegradation, and (3) develop enabling technologies in the synthesis of novel multifunctional materials for drug delivery and cellular/tissue engineering.	263-2998/262-1416 wjkao@pharmacy.wisc.edu
James Keck Biomolecular Chemistry (Microbiology, Biophysics)	Structural and mechanistic bases of DNA replication, recombination, and repair in bacteria. Combine X-ray crystallographic, biochemical and genetic methods. Focused on the functions of the RecQ family of DNA helicases in recombination and replication as they're important to normal genomic maintenance. Mutation in any of three human RecQ homologs results in predisposition to a variety of cancers. Aim to understand the mechanistic basis for these abnormalities and to uncover the DNA metabolic pathways in which RecQ proteins play a role.	263-1815 jlkeck@wisc.edu
Patricia Keely Pharmacology	Interested in understanding, at a molecular level, how cellular interactions with the ECM determine differentiation and epithelial polarization, and how these interactions are altered during carcinogenesis to result in invasive, metastatic carcinoma.	265-2398 pjkeely@wisc.edu
Nancy P. Keller Plant Pathology	Investigates the molecular genetics of mycotoxin synthesis and the fungus/seed interaction. Focuses on Aspergillus and Fusarium spp. Current studies include elucidating the role of signal transduction in Aspergillus sporulation and mycotoxin biosynthesis, molecular crosstalk governing the funal/seed interaction, microarray studies of metabolic pathways leading to mycotoxin formation.	262-9795 npk@plantpath.wisc.edu
Laura Kiessling (1) Chemistry (Biochemistry)	Modulating signaling pathways in bacteria, controlling B cell receptor responses in the immune system, and modulating protein- carbohydrate interactions that are important for signal transduction, cell - cell recognition and adhesion.	262-0541/262-9234 kiessling@chem.wisc.edu
Patricia Kiley Biomolecular Chemistry (Microbiology)	Studies Escherichia coli global regulator, FNR that functions in regulating the transcription of genes necessary for adaptation to anaerobic growth conditions. Interested in determining how FNR functions as a transcriptional activator under anaerobic conditions by identifying the activation regions of this protein and its corresponding interacting domains on RNA polymerase. Studying how FNR acts as an oxygen sensor to sense changes in cellular oxygen levels. Found that oxygen sensing occurs through an oxygen-labile iron-sulfur cluster. This finding has led us to study the in vivo pathway by which iron-clusters are assembled and insert into FNR and other iron-sulfur cluster containing proteins.	262-6632 pjkiley@wisc.edu
Judith Kimble Biochemistry (Genetics)	To understand the regulation of animal development at the molecular level, with particular interested in controls of cell fate and patterning within multicellular tissues. Our experimental approach relies on the powerful genetics, simple anatomy and complete genome sequence of the nematode C. elegans. This model organism provides a way to identify and analyze regulators that are used throughout the animal kingdom for basic processes of development. Our work concerns three primary areas: Signal transduction and regulation of proliferation; Translational control and controls of cell fate; and Organogenesis.	262-6188 jekimble@facstaff.wisc.edu
Robert Landick Bacteriology	Regulatory mechanisms that control gene expression through changes in RNA chain elongation in organisms ranging from bacteria and humans.	(608)231-0213 landick@bact.wisc.edu
Youngsook Lee Anatomy	Advance our understanding of the genetic controls that guide cardiovascular development and maintenance of normal cardiac phenotype.	(608) 265-6352/(608)262-3327 youngsooklee@facstaff.wisc.edu
Lingjun Li Pharmaceutical Sciences	Research will (a) develop improved MS-based methods of neuropeptide and protein analysis both at large-scale and micro-scale and (b) provide essential information on understanding the mechanisms of neuromodulation of behaviorally relevant neural circuits and peptide evolution and peptide regulation.	265-8491 lli@pharmacy.wisc.edu
David M. Lynn Chemical and Biological Engineering (Chemistry)	Design, synthesis, and evaluation of functional polymers and nanostructured organic materials for the controlled release and localized delivery of DNA and small molecule therapeutics.	262-1086 dlynn@engr.wisc.edu
Gary Lyons Anatomy	Characterization of novel genes in the mouse cardiovascular system using gene trapping in embryonic stem cells	262-2874/262-3327 gelyons@facstaff.wisc.edu
James Malter Pathology (Neuroscience)	Study of eukaryotic cell regulation of cytoplasmic stability of mRNA, focusing on the cytokine and oncogene mRNAs.	263-6043/263-1231 jsmalter@wisc.edu
Christos Maravelias Chemical and Biological Engineering	The objective of our research is to develop theory, models and algorithms for the solution of important and fundamental problems in the area of Process Systems Engineering. To address these problems we primarily use optimization techniques from various scientific fields, such as Operations Research and Computer Science, as well as traditional tools of Systems Engineering, such as simulation and control theory.	265-9026 christos@engr.wisc.edu
John Markley Biochemistry	NMR spectroscopy; sequence-structure-function relationships in proteins.	(608) 263-9349 markley@nmrfam.wisc.edu
Thomas F. Martin Biochemistry (Zoology / Neuroscience)	Utilization of reverse genetics and antisense RNA methods to alter function and expression levels of these key proteins in an established neuroendocrine cell line (PC12 cells); studies of interactions (with proteins and phospholipids) that mediate the function of CAPS utilizing biochemical and mutational analyses; studies of CAPS protein phophorylation and the neurotranmitters/meuropeptides involved in affective disorders such as depression.	263-2427/263-1163 tfmartin@facstaff.wisc.edu
Patrick Masson Genetics	Molecular genetic analysis of Arabidopsis thaliana root-growth behavior in response to mechanical information; Molecular genetic analysis of anisotropic cell expansion and its contribution to the morphogenesis of plant organs.	265-2312/265-2313 phmasson@wisc.edu
Kristyn Masters Biomedical Engineering	Biomaterials and Tissue Engineering.	(608) 265-4052 kmasters@wisc.edu
Katherine D. McMahon Civil & Environmental Engineering (Microbiology)	Microbial ecology of natural and engineered systems, with an emphasis on biologically mediated waste treatment processes. Molecular tools used to investigate microbial community structure and function in activated sludge, subsurface environments, and freshwater bodies. Metabolic engineering is used to elucidate pathways of biocatalysis and biodegradation. Contribution of stress response mechanisms to population structure and performance in activated sludge; bioflocculation; phosphate metabolism; and, antibiotic resistance in environmental populations.	263-3137 tmcmahon@engr.wisc.edu
M. Elizabeth Meyerand Medical Physics	Magnetic Resonance Imaging (MRI)	263-1685/262-1352 memeyerand@facstaff.wisc.edu
Julie Mitchell Mathematics/ Biochemistry	Protein Interactions at the structural and systems level. Particularly interested to use computation to model and predict the behavior of protein-protein and protein-DNA/RNA systems.	(608) 263-6819 mitchell@math.wisc.edu
Deane Mosher Biomolecular Chemistry	Studies of the biochemistry of the extracellular matrix and blood coagulation.	262-1576/263-1836 dfmosher@facstaff.wisc.edu
Regina M. Murphy Chemical and Biological Engineering (Biomedical Engineering)	Protein-protein and protein-cell interactions using physiochemical techniques, and developing quantitative models to describe these interactions.	262-1587 regina@engr.wisc.edu
William L. Murphy Biomedical Engineering, (Materials Science and Engineering, Pharmacology )	Creation of novel materials using bioinspired approaches -- Development of biomaterials for tissue regeneration (tissue engineering) -- Novel approaches to drug delivery and gene therapy -- Delivery of developmental signals to influence stem cell activity	262-2224 wlmurphy@wisc.edu
Robert W. Nickells Ophthalmology and Visual Sciences and Biomolecular Chemistry	Characterizing the molecular basis and pathways of the death of retinal ganglion cells and develop or acquire transgenic or knock-out mice to directly test the function and role of target genes in this process. Other approaches used are classical mouse genetics and the isolation of differentially expressed genes to identify novel products that may be involved. Many of the projects cross over into translational research that require clinical input and practice. An example of this is the gene therapy initiative that they have been pursuing to control wound healing in animal models of glaucoma trabeculectomy surgery.	265-6037 nickells@facstaff.wisc.edu
Daniel R. Noguera Civil & Environmental Engineering	Combination of mathematical modeling and microbiological tools to study the microbial ecology of natural and engineered systems, with emphasis in microbial aggregates and biofilms. Bioremediation.	263-7783 noguera@engr.wisc.edu
Brenda Ogle Biomedical Engineering	The overall goal of our laboratory is to transform the theories of regenerative medicine into clinical practice.	608/265-8267 ogle@wisc.edu
Marisa Otegui Botany	Structural and functional aspects of multivesicular bodies (MVBs) in plant cells.	265-5703 otegui@wisc.edu
Sean Palecek Chemical & Biological Engineering	Regulation of cell adhesion and polarity by chemical signaling networks. Design of novel assays for global analysis of gene transcription and protein activity.	262-8931 palecek@engr.wisc.edu
Ann C. Palmenberg Biochemistry	Molecular biology of RNA picornaviruses; protein translation, proteolytic processing; RNA synthesis; viral pathogenesis; viral vaccines, vaccine vectors; computer-based sequence analysis.	262-7519/262-7228 acpalmen@facstaff.wisc.edu
Sara Patterson Horticulture	Genetics, molecular biology, and biochemistry of plant development. Specific interests include understanding the mechanisms that regulate cell separation and adhesion using floral organ abscission in Arabidopsis as a model system.	262-1543/262-8332 spatters@wisc.edu
Joel Pedersen Soil Science	Behavior of organic chemicals in soil, sediment and water systems; soil biochemistry; ecotoxicology	263-4971 joelpedersen@wisc.edu
Donna Peters Pathology	Protein-protein interactions involved in the assembly of the extracellular matrix. Regulation of Extracellular Matrix formation.	262-4626/262-7576 dmpeters2@wisc.edu
Richard E. Peterson Pharmacy	The goal is to determine consequences of perinatal TCDD exposure on prostate development in the C57BL/6 mouse and elucidate mechanisms involved	263-5453/262-4751 REPeterson@pharmacy.wisc.edu
Brian Pfleger Chemical and Biological Engineering	Developing microorganisms capable of producing small molecules of significant social, economic, and scientific value from renewable resources.	890-1940/262-5434 pfleger@engr.wisc.edu
George N. Phillips, Jr Biochemistry (Computer Science)	The overall goal of the research is to relate the three-dimensional structure and dynamics of proteins to their biological functions. We use techniques of X-ray crystallography and electron microscopy to elucidate the molecular structures of proteins. Extensive use is made of modern computational methods to analyze the structures and their dynamics. Proteins are also reengineered for basic science, medical, or industrial applications.	263-6142 phillips@biochem.wisc.edu
Richard Proctor Medical Microbiology & Immunology	Bacterial pathogenesis: Understanding at cellular and molecular levels. Clone and characterize genes involved in electron transport that allow variant S. aureus to persist in tissues; define molecular and biochemical pathways of endotoxin activation of macrophages; inhibition of endotoxin activity by lipid A precursors and by adenine nucleotide derivatives.	263-5591 rap@wisc.edu
Ronald Raines Biochemistry (Chemistry)	Chemical biology; protein design and engineering; protein folding; enzymology.	262-8588 raines@biochem.wisc.edu
Ivan Rayment Biochemistry	Structure and function of proteins by x-ray diffraction analysis	(608) 262-0437 ivan_rayment@biochem.wisc.edu
M. Thomas Record, Jr. Chemistry (Biochemistry)	Specificity, stability and mechanisms of formation of protein-nucleic acid complexes; biophysical studies of the E. coli cytoplasm; polyelectrolyte properties of nucleic acids and their complexes	262-5332 record@chem.wisc.edu
Jennifer Reed Chemical & Biological Engineering	Building, analyzing and testing computational models of microoranisms with application in bioremediation and alternative fuel production, involving metabolic and regulatory models for organisms with relevent industrial, environmental, & pharmaceutical applications. Model contruction & developing computational methods for microbial strain design.	262-0188 reed@engr.wisc.edu
Gail Robertson Physiology	Molecular mechanisms of ion channel function	265-3339/265-3162 robertson@physiology.wisc.edu
Eric Roden Geology & Geophysics	Biogeochemistry of aquatic environments, emphasizing in situ rates of and controls on microbial metabolism in anaerobic soils and sediments; role of anaerobic microbial processes in geochemical cycling and energy flow in sedimentary systems; physiology and ecology of anaerobic respiratory bacteria; influence of anaerobic microbial processes on the mobility and fate of metals and organic contaminants in soils/surface sediments and groundwater aquifer sediments.	(608) 890-0724/(608) 443-9048 eroden@geology.wisc.edu
Linda Schuler Comparative Biosciences (Endocrinology Reproductive Physiology)	Prolactin-related growth factors expressed by the placenta; their structure, genes, regulation, receptor structure and action.	263-9825/263-4850 schulerl@svm.vetmed.wisc.edu
David C. Schwartz Chemistry	The development of new genome analysis systems which exploits novel macromolecular phenomena	265-0546 dcschwartz@wisc.edu
Ben Shen Pharmacy (Chemistry)	Microorganisms produce many biologically active substances representing a vast diversity of fascinating molecular architecture not available in other systems. Research interests center on secondary metabolite biosynthesis in microorganisms, gene cloning and expression, enzyme reaction mechanisms, metabolic pathway engineering, and combinatorial biosynthesis. Currently working on: (1) the hybrid nonribosomal peptide synthetase and polyketide synthase hypothesis (2) the genetic and biochemical basis for the biosynthesis of the enediyne family of antitumor antibiotics and (3) the stereospecificity of polyketide synthase.	263-2673 bshen@pharmacy.wisc.edu
J. Leon Shohet Electrical and Computer Engineering	Biocompatability. Gas plasma technology, materials science, surface analysis of the adhesion of blood components, in-vivo and ex-vivo testing of artificial blood vessels, numerical and experimental measurement of flow properties affecting adhesion of blood components. Modeling the sodium concentrating mechanism in the renal medulla.	262-1191 shohet@engr.wisc.edu
Eric Shusta Chemical and Biological Engineering	Noninvasive delivery of small molecule pharmaceuticals and biopharmaceuticals to the brain is hindered by the presence of the blood-brain barrier. We are focused on overcoming this barrier by developing noninvasive, antibody-based delivery methods that target drugs to the brain.	262-1092 shusta@engr.wisc.edu
Lloyd M. Smith Chemistry	The development of novel methods and approaches for the analysis and manipulation of biomolecules. Major interest areas include biological mass spectrometry, BNA computing, surface chemistry, surface detection methods (fluorescence, surface plasomon resonance), and the analysis of genetic variations.	263-2594/262-2021 smith@chem.wisc.edu
Paul M. Sondel Pediatrics (Human Cancer Biology, Genetics)	Interactions between tumor cells and the immune system, with an emphasis on application of these results to the clinical immunotherapy of patients with cancer.	263-9069/263-8556 pmsondel@facstaff.wisc.edu
Gary Splitter Animal Health & Biomedical Sciences	Evaluates host-pathogen interactions to better understand host defense and pathogen evasion mechanisms that define a disease process. The following are specific areas of emphasis: Transgenic Antivirals for bovine leukemia virus, Brucella-host interactions using microarrays and gene knockout animals, and Gene therapy using bovine herpes tegument gene, VP22, that has the unusual property of intra-and inter-cellular trafficking.	262-1837/262-0472 gas@svm.vetmed.wisc.edu
Rob Striker Medicine (Medical Microbiology)	Use genetics and biochemistry to determine what selective pressure exists on RNA viruses in specific medical environments, and why. Has implications for basic understanding of how RNA viruses replicate plus medical significance of how to treat viral infections. RNA viral evolution is a major issue for drug and vaccine development.	262-4725/263-5794 rtstriker@wisc.edu
Michael Sussman Biochemistry	Studying key transport and signal transducing proteins in the plasma membrane of higher plants and fungi, including the structure and function of these enzymes. Also involved in developing new genomic technologies for investigating the plasma membrane. Examples include a genome wide method for creating 'knockout' plants, development of a benchtop machine for creating DNA chips 'on the fly' and the use of mass spectrometers for analyzing the plant proteome and metabilome. We focus on Arabidopsis thaliana because its genome is completely sequenced and it is easy to create mutants in any gene of interest.	262-8608 msussman@facstaff.wisc.edu
Adel M. Talaat Pathobiological Sciences	The research in my laboratory involves the use of innovative approaches to understand the basics of bacterial pathogenesis and evolution on a genome-wide scale. Definitely, we advocate the idea of “useful genomics” where genome-wide protocols are used to better understand the disease process or to discover novel vaccine and drug targets.	262-2861/ 262-3711 talaat@svm.vetmed.wisc.edu
Michael G. Thomas Bacteriology	The focus of our research is the biosynthesis of bacterial secondary metabolites, specifically those made by Streptomycetes and Cyanobacteria. Through the use of genomics, genetics, biochemistry, molecular biology and chemistry we are trying to understand the logic of how these chemically complex molecules are biosynthesized and exported by the producing bacterium, as well as how their production is regulated by the cell. Once these questions have been addressed, we can begin to rationally reprogram the genetic machinery to generate new structural diversity or to increase.	263-9075 thomas@bact.wisc.edu
James Thomson Anatomy	Understanding how primate embryonic stem (ES) cells choose between self-renewal, death and differentiation to specific lineages. Primate ES cells are capable of long term undifferentiated proliferation and yet maintain the ability to from many, if not all, of the cells that make up the adult including gut and hematopoietic cells (mesoderm); skin, astrocytes, oligodendrocytes, and neurons (ectoderm). Studying factors that promote ES cell self-renewal and differentiation of primate ES cells to hematopoietic, neural and pancreatic cells. (See news article)	263-3585 THOMSON@PRIMATE.WISC.EDU
Jon Thorson Pharmaceutical Sciences	Understanding and exploiting biosynthetic pathways in various microorganisms, microbial pathway genomics, chemo-enzymatic synthesis, elucidation of novel enzyme mechanisms, study of resistance to highly reactive metabolites in microorganisms, structure-based enzyme engineering toward the generation of novel catalysts and glycorandomization of natural products.	262-3829 jsthorson@pharmacy.wisc.edu
Ray Vanderby Biomedical Engineering	Tissue mechanics , tissue engineering , connective tissue healing, orthopedic biomechanics .	263-9593 vanderby@orthorehab.wisc.edu
Tomy Varghese Medical Physics Electrical and Computer Engineering	Elastography, Signal & Image Processing Applications in Medical Imaging , Ultrasound Tissue Characterization	265-8797 tvarghese@wisc.edu
Ronald Wakai Medical Physics	Magnetoencephalography (MEG) and magnetocardiography (MCG)	265-4988/262-2170 rtwakai@facstaff.wisc.edu
David Wassarman Pharmacology	Interested in understanding how transcriptional regulatory mechanisms are regulated by signaling pathways. Focuses on understanding how the TAF1 component of the general transcription factor TFIID regulates RNA polymerase II transcription in response to Ras-mediated signal transcription pathways.	262-6648 dawassarman@wisc.edu
Douglas Weibel Biochemistry	My research group uses an interdisciplinary approach to study bacterial cell biology and behavior based on a fusion of techniques from cell biology, bacterial genetics, chemical biology, materials science and engineering, and microbiology.	890-1342 weibel@biochem.wisc.edu
James C. Weisshaar Chemistry	Using fluorescence microscopy to study the molecular mechanisms underlying biological processes.	262-0266 weisshaar@chem.wisc.edu
Rod Welch Medical Microbiology & Immunology	Molecular pathogenesis of human virulent strains of Escherichia coli. Currently studying the role of D-serine as a co-regulator of virulence gene expression of uropathogenic E. coli. Also examining the structure and function of an extracellular metalloprotease produced by E. coli O157:H7 strains.	(608) 263-2700/(608) 262-7814 rawelch@wisc.edu
Marvin Wickens Biochemistry	Understanding how RNAs and proteins interact, and the biological importance of those interactions. Developed a rapid and facile method for detecting and analyzing RNA-protein interaction in vivo, with applications in the development of therapeutics, the analysis of RNA viruses, aging, and development. Concentrates on biological problems concerning RNA processing, translation mRNA turnover and mammalian RNA viruses.	262-8007/262-0347 wickens@biochem.wisc.edu
Christiane Wiese Biochemistry	Molecular mechanisms of mitotic spindle assembly and microtubule nucleation; cell-cycle dependent regulation of spindle assembly proteins; centrosome structure and function	(608) 263-7608 wiese@biochem.wisc.edu
Jon Woods Medical Microbiology & Immunology	Microbial molecular pathogenesis and host interactions, focusing on the dimorphic fungus Histoplasma capsulatum. Interests include environmental gene regulation, particularly related to the host environment during infection, and mechanisms facilitating virulence.	265-6292 jpwoods@wisc.edu
Wei Xu Oncology	Estrogen receptor signaling pathways; histone methylation and epigenetic transcriptional regulation; protein arginine methylation	265-5540 wxu@oncology.wisc.edu
John Yin Chemical and Biological Engineering	Developing systems biology approaches to quantitatively understand how viruses grow and infections spread, virus-host interactions, innate and adaptive immunity; applications of microfluidics in virology.	265-3779/Fax 262-5434 yin@engr.wisc.edu
Martin Zanni Chemistry	Study transient protein dynamics using new multidimensional infrared spectroscopies like 2D IR spectroscopy. For instance, my group is studying the gating mechanism of the M2 membrane channel from the Influenza virus and the transient structures of amyloid fiber formation involved in type 2 diabetes.	262-4783 zanni@chem.wisc.edu